The Route of All Evil

While literally it means 'bad luck', the expression is used dismissively to brush off someone's problem, signaling zero sympathy. The tone is what makes it non-compositional: a compassionate 'that's unfortunate' versus a cold 'not my problem'.

Fixed phrase expressing that a condition holds regardless of circumstances. The 'no importa' here functions as a concessive connector, not as 'it doesn't matter' in isolation.

A euphemistic but clearly vulgar expression used to reject something with contempt. The show uses it in a deliberately roundabout way for comic effect, but the meaning and register are unmistakably rude.

Expresses mild to moderate frustration or annoyance. 'Fastidio' (annoyance, bother) is broadly used in Latin American Spanish; the exclamatory 'qué + noun' structure intensifies it.