Perdida

Used in police and journalistic contexts to indicate a major criminal target or influential person. Equivalent to English 'big fish'.

Used when someone has to confront a difficult situation publicly, often with the press or authority. Not inherently negative, can mean stepping up or taking responsibility.

Figurative use meaning to pursue a clue or line of inquiry until something emerges. Common in investigative contexts.

In this register, often carries a disapproving sense: someone is getting involved where they are not welcome or where it causes problems. Context determines whether it is neutral or negative.